Skip to main content
. 2022 Oct 28;23(21):13070. doi: 10.3390/ijms232113070

Figure 5.

Figure 5

Transcriptome alterations in colon of MIAO orally gavaged with Parabacteroides goldsteinii MTS01. Dot plots of the significantly upregulated (normalized enrichment score [NES] > 1 and false-discovery rate [FDR] q value < 0.25) and downregulated ([NES] < −1 and FDR q value < 0.25) gene sets from gene set enrichment analysis of the MIAO + Pg group compared to the MIAO group (top 20 gene sets in GO_BP, GO_MF and GO_CC) are presented in (A,B), respectively. Gene sets with similar functions were labeled in color, and the functions were also added. Five genes contributing to the leading-edge subset within the gene sets (immune responses such as B cell receptor, lipopolysaccharide receptor, and chemokine responses; synapse responses such as synaptic membrane exocytosis) as validated by quantitative RT-PCR are presented in (C–G). Data are presented as the mean ± standard deviation. * p < 0.05; ** p < 0.01(unpaired Student’s t-test). MIAO + Pg, MIAO treated with P. goldsteinii MTS01.