Table 1.

Diagnostic criteria for PIMS -TS or MIS-C.

	World Health Organization [4]	Royal College of Pediatrics and Child Health (UK)	Centers for Disease Control and Prevention (US) [1]
Age	0–19 years of age.	0–18 years of age.	Individual aged <21 years.
Clinical feature	Fever >3 days and 2 of the following: (a) Rash or bilateral nonpurulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet). (b) Hypotension or shock. (c) Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities (including ECHO findings or elevated Troponin/NT-proBNP), (e) Acute gastrointestinal problems (diarrhea, vomiting, or abdominal pain).	Persistent fever > 38.5 °C. Evidence of single or multiorgan dysfunction (shock, cardiac, respiratory, renal, gastrointestinal or neurological disorder) with additional features, which may include children fulfilling full or partial criteria for KD.	Fever ≥38.0 °C for ≥24 h, or report of subjective fever lasting ≥24 h. Severe illness necessitating hospitalization. 2 or more organ systems affected (e.g., cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic, and neurological.
Laboratoristic criteria	Evidence of coagulopathy (by PT, PTT, elevated D-dimer). Elevated ESR, C-reactive protein, or procalcitonin. No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal, or streptococcal shock syndromes.	Neutrophilia, elevated CRP, and lymphopenia	Elevated CRP, ESR, fibrinogen, procalcitonin, D-dimer, ferritin, LDH, or IL-6, elevated neutrophils, reduced lymphocytes, and low albumin.
COVID-19 relationship	Evidence of COVID-19 (RT-PCR, antigen test or serology positive), or likely contact with patients with COVID-19.	SARS-CoV-2 PCR testing may be positive or negative.	Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to onset of symptoms.