Table 2.

Detection of DARA peptide sequences by mass spectrometry on MM PB EVs.

	DARA-Specific Sequences only Detected in DARA Treated MM Patient EVs
MM Patient	1	2	3	4	5	6	7	8	9	10
Light chain		SNWPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR		SLEPEDFAVY	SNWPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR	SNWPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSK
Heavy chain	STSGGT		SGGTAA		GPSVFPLAPSSKSTSGGTAALGCLVK	GGTAAL	GPSVFPLAPSSKSTSGGTAALGCLVK	SCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISR		TKGPSVF
	KAKGQP				SGVHTF	ALTSGV				STKGPSVFPLA
					KPSNTK	TYICNVNHK				KGPSVF
					VEPKSCDK	SCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISR				HKPSNTKVD
						PSVFLFP				EEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYK

The DARA peptides that were detected in MM patient EVs, containing sequences not found in healthy control EVs, are listed for each patient with the unique amino acids underlined.