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Pep186-200 neutralizes increasing amounts of LPS in the LPS-induced priming of human blood. Human blood was primed for 30 min at 37°C with 1 to 10 ng of ReLPS per ml and 30 μM pep186-200. An fMLP-induced chemiluminescence in 10-fold diluted blood was measured for 10 min. Data represent the percent inhibition of the 10-min integral area under the curve (10′ AUC) of three separate experiments ± standard error of the mean.
