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MCC950 inhibited MnCl2-induced KHSRP and NLRP3 genes gradually in a dose-dependent manner. N2a cells were pre-treated for 1 h with MCC950 (0.1, 1 and 10 µM) and later exposed to MnCl2 (500 µM) for 24 h. (a) relative KHSRP mRNA expression; (b) relative NLRP3 mRNA expression. All mRNA values were normalized to the housekeeping mRNA, GAPDH, and expressed as a fold-induction over the control sample (set at a value of 1). Data represented as mean ± SEM. *** p < 0.0001 vs. control group.
