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. 2022 Oct 30;23(21):13224. doi: 10.3390/ijms232113224

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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KHSRP, and NLRP3 protein levels were upregulated by MnCl₂, and further inhibited in a dose-dependent fashion by MCC950 in rat brain samples estimated by Western blot. (a–c) Western blot images and histograms for KHSRP and NLRP3. Relative protein for KHSRP and NLRP3 protein intensity values calculated post normalization to the housekeeping protein, GAPDH, and expressed as a fold-induction over control sample (set at a value of 1). Data represented as mean ± SEM. ** p < 0.001, *** p < 0.0001 vs. control group.