FIG. 3.

Influence of class I or class II proteins on the generation of P. gingivalis-specific antibodies. P. gingivalis-reactive IgG was increased in C57BL/6J and β₂m-knockout (β2m KO) mice orally infected with P. gingivalis (∗, different from sham-infected controls at P < 0.05) but not in A_β-knockout (Aβ KO) mice. P. gingivalis-reactive IgM was increased in orally infected C57BL/6J mice (∗) but not in infected β₂m- or A_β-knockout mice. Both sham-infected and infected β₂m-knockout mice had less P. gingivalis-reactive IgG than sham-infected or infected C57BL/6J mice, as did infected A_β-knockout mice (Φ, different from C57BL/6J at P < 0.05). Anti-P. gingivalis IgA was not found in any of the mouse strains tested (data not shown).