FIG. 7.

PAF mediates resistance in mice infected with T. cruzi. BALB/c mice were infected with 10⁴ (A) or 10³ (B) blood trypomastigotes and treated with WEB 2170 (●) or with vehicle (○) 4 h before and again once daily after infection with T. cruzi. Parasitemia (A) and survival rates (B) were evaluated during the acute phase. Lines represent means and SD of data obtained with 10 mice per group in one of three independent experiments. ∗, P < 0.05 compared to the values obtained for parasitemia in vehicle-treated mice.