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Therapeutic effects of MTX, CS12192, or the combination of CS12192 and MTX on joint histopathology of CIA rats. (A) knee and (B) ankle joint tissue sections of CIA rats in different groups by Hematoxylin and Eosin staining. Scale bar = 50 µm. Inflammation scores were calculated as described in the Methods. Data represent the mean ± SEM for groups of 10 rats from different groups. * p < 0.05; ** p < 0.01; and *** p < 0.001 as indicated.
