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Therapeutic effects of MTX, CS12192 or the combination of CS12192 and MTX treatments on serum levels of CRP, RF, and ANA in CIA rats. Serum levels of CRP, RF, and ANA in CIA rats were measured by ELISA on day 28 after the first immunization. (A) Serum levels of CRP. (B) Serum levels of rheumatic factor (RF). (C) Serum levels of anti-nuclear antibody (ANA). Each dot represents one rat. * p < 0.05; ** p < 0.01; and *** p < 0.001 as indicated.
