Table 1.
Experimental Design of the current study.
| Group Name and Number of Rats | Day 0 (First Immunization) | Day 7 (Second Immunization and Stat Point of Treatment) | Day 35 |
|---|---|---|---|
| Untreated Group (5) | Normal rats | Normal rats | End of Experiments |
| CIA * group (10) | CII-IFA * | CII-IFA+PBS * (1 ml/qd *) | |
| MTX * group (10) | CII-IFA | CII-IFA +MTX (0.2 mg/kg/qd) | |
| CS12192 group (10) | CII-IFA | CII-IFA +CS12192 (40 mg/kg/bid *) | |
| MTX + CS1219 group (10) | CII-IFA | CII-IFA +MTX (0.2 mg/kg/qd) + CS12192 (40 mg/kg/qd) |
* Abbreviation: collagen-induced arthritis, CIA; type II collagen in complete Freund’s adjuvant, CII-IFA; methotrexate, MTX; phosphate-buffered saline, PBS; quaque die, qd; bis in die, bid.