Table 1.
Patient characteristics.
| Characteristics | CYP3A5 Expressers (n = 110) |
CYP3A5 Nonexpressers (n = 78) |
p-Value |
|---|---|---|---|
| On the day of transplantation | |||
| Recipient age, years | 45.8 ± 11.7 | 44.7 ± 11.6 | 0.538 b |
| Body weight, kg | 58.2 ± 11.2 | 58.0 ± 11.7 | 0.889 b |
| Female, n (%) | 49 (44.5) | 35 (44.9) | 0.965 a |
| Previous KT, n (%) | 7 (6.4) | 3 (3.8) | 0.527 c |
| Panel reactive antibody > 20%, n (%) | 19 (17.3) | 12 (15.4) | 0.731 a |
| Human leukocyte antigen mismatches, no. | 3.0 [2.0, 4.0] | 3.0 [2.0, 4.0] | 0.973 d |
| Deceased donor, n (%) | 56 (50.9) | 36 (46.2) | 0.520 a |
| Donor age, years | 36.5 [28.8, 46.2] | 38.0 [28.2, 46.2] | 0.723 d |
| Cold ischemic time, minutes | 253.5 [20.8, 1078.5] | 68.0 [21.5, 1047.0] | 0.907 d |
| Renal replacement therapy before KT, n (%) | - | - | 0.234 c |
| Preemptive transplantation | 2 (1.8) | 4 (5.1) | - |
| Hemodialysis | 97 (88.2) | 70 (89.7) | - |
| Peritoneal dialysis | 11 (10.0) | 4 (5.1) | - |
| At month 6 post-kidney transplantation | |||
| Serum creatinine, mg/dL | 1.3 [1.0, 1.6] | 1.2 [1.0, 1.5] | 0.377 d |
| Hemoglobin, g/dL | 12.9 ± 1.8 | 13.2 ± 1.8 | 0.353 b |
| Serum albumin, g/dL e | 4.3 [4.1, 4.6] | 4.3 [4.2, 4.6] | 0.495 d |
| At month 9 post- kidney transplantation | |||
| Serum creatinine, mg/dL | 1.3 [1.0, 1.5] | 1.2 [1.0, 1.5] | 0.475 d |
| Hemoglobin, g/dL | 13.2 ± 1.8 | 13.5 ± 1.8 | 0.272 b |
| Serum albumin, g/dL f | 4.4 [4.2, 4.6] | 4.4 [4.2, 4.6] | 0.742 d |
| At month 12 post- kidney transplantation | |||
| Serum creatinine, mg/dL | 1.3 [1.0, 1.5] | 1.2 [1.0, 1.5] | 0.327 d |
| Hemoglobin, g/dL | 13.4 ± 1.7 | 13. 6 ± 1. 7 | 0.421 b |
| Serum albumin, g/dL g | 4.4 [4.2, 4.6] | 4.4 [4.3, 4.7] | 0.527 d |
Continuous values are expressed as mean ± SD or median [interquartile range] for comparison reasons. a Chi-square test. b Student’s t-test. c Fisher’s exact test. d Mann–Whitney U test. e Serum albumin at month 6 was that of 137 patients only. f Serum albumin at month 9 was that of 128 patients only. g Serum albumin at month 12 was that of 125 patients only.