Table 2.

Combinatorial indices (CI) as determined by isobole testing at the IC₃₀, IC₅₀ and IC₇₀ values for paclitaxel or sabizabulin when paired with lapatinib in JIMT and AU565 HER2+ cell lines. Results are representative of three biological replicate isobole assays. Values < 1.0 indicate synergistic drug action, while values of approximating 1.0 are indicative of an additive effect, whereas values > 1.0 suggest antagonism.

	JIMT		AU565
	Lapatinib + 3 nM Paclitaxel	Lapatinib + 30 nM Sabizabulin	Lapatinib + 2 nM Paclitaxel	Lapatinib + 10 nM Sabizabulin
IC30	1.35	0.48	1.49	0.97
IC50	1.17	0.22	1.49	0.89
IC70	1.14	1.02	1.53	0.88