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. 2022 Nov 7;27(21):7640. doi: 10.3390/molecules27217640

Table 1.

Anti-HIV Activity and Cytotoxicity in MT-4 Cells Infected with HIV-1 IIIB and HIV-2 ROD.

graphic file with name molecules-27-07640-i001.jpg
Compound ID R1 R2 EC50 a (μM) CC50 b (μM) SI c
HIV-1 IIIB HIV-2 ROD HIV-1 HIV-2
FTC-2 F H 5.36 ± 0.98 15.56 ± 1.06 >265.69 >49.57 >17.08
TC-2 H H 29.07 ± 4.23 19.72 ± 6.42 261.13 ± 33.14 8.98 13.24
TD-1a H graphic file with name molecules-27-07640-i002.jpg 16.81 ± 0.91 4.86 ± 1.71 86.54 ± 29.24 5.15 17.81
TD-1b H graphic file with name molecules-27-07640-i003.jpg >34.80 16.22 ± 17.16 34.80 ± 5.75 N.D.d 2.15
TD-1c H graphic file with name molecules-27-07640-i004.jpg 18.90 ± 2.66 6.59 ± 1.63 61.65 ± 8.44 3.26 9.36
TD-1d H graphic file with name molecules-27-07640-i005.jpg 17.88 ± 2.68 7.92 ± 0.83 81.42 ± 22.66 4.55 10.28
TD-1e H graphic file with name molecules-27-07640-i006.jpg >25.48 >25.48 25.48 ± 2.90 N.D. N.D.
TD-1f H graphic file with name molecules-27-07640-i007.jpg >23.51 >23.51 23.51 ± 2.79 N.D. N.D.
TD-1g H graphic file with name molecules-27-07640-i008.jpg 25.60 ± 7.51 20.48 ± 8.49 58.27 ± 4.85 2.28 2.85
TD-1h H graphic file with name molecules-27-07640-i009.jpg 29.62 ± 4.34 10.67 ± 3.66 53.13 ± 5.12 1.79 4.98
TD-1i H graphic file with name molecules-27-07640-i010.jpg 19.09 ± 5.08 15.25 ± 0.55 96.17 ± 19.83 5.04 6.31
TD-1j H graphic file with name molecules-27-07640-i011.jpg 16.77 ± 0.78 17.83 ± 2.79 137.19 ± 22.50 8.18 7.69
TD-1k H graphic file with name molecules-27-07640-i012.jpg >27.59 >27.59 27.59 ± 3.18 N.D. N.D.
TD-1l H graphic file with name molecules-27-07640-i013.jpg >31.87 >31.87 31.87 ± 1.73 N.D. N.D.
TD-1m H graphic file with name molecules-27-07640-i014.jpg >189.23 17.14 ± 2.49 189.23 ± 2.19 N.D. 11.04
PF74 - - 1.08 ± 0.24 5.76 ± 2.14 >293.75 >271.99 >51.00

a EC50: the concentration of the compound required to achieve 50% protection of MT-4 cells against the HIV-induced cytotoxicity effect, determined in at least triplicate against HIV in MT-4 cells; b CC50: the concentration of the compound required to reduce the viability of uninfected cells by 50%, determined in at least triplicate against HIV in MT-4 cells; values were averaged from at least three independent experiments; c SI: selectivity index, the ratio of CC50/EC50. d N.D.: not determined.