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Superposition of AM6538@CB1-R (5TGZ from PDB) (pink) and AM10257@CB2-R (5ZTY from PDB) (purple). The crystal structure of human CB2-R in complex with antagonist AM10257 and crystal structure of human CB1-R in complex with AM6538 shows the conformational lock holding the binding site in the ligand-binding conformation [32,85]. Modified using Schrödinger Release software 2021-4: Maestro, Schrödinger, LLC, New York, NY, 2021 [32,85].
