Table 3.

Chemical structures of cannabinoids and their affinity to the CB receptors.

Cannabinoid	Receptor Affinity	Reference
Phytocannabinoids
${\Delta }^9$-$\mathrm{tetrahydrocannabinol}({\Delta }^9$-THC)	CB1-R and CB2-R agonist	[150]
(-)-Cannabidiol (CBD)	No activity at CB1-R or CB2-R	[150]
Endogenous cannabinoids
Anandamide	Greater CB1-R than CB2-R agonist TRPV1 agonist	[104]
2-Arachidonoyl glycerol	CB1-R and CB2-R agonist	[70]
Virodhamine	Greater CB1-R than CB2-R agonist	[150]
N-Arachidonoyl dopamine	Greater CB1-R than CB2-R agonist TRPV1 agonist	[150]
Noladin-ether	Greater CB1-R than CB2-R agonist	[150]
Synthetic cannabinoids
Aminoalkylindole WIN 55,212-2	Highly selective CB2-R agonist.	[151]
Benzoylindole AM694	Potent CB receptor agonist. Highly selective for CB2 receptor.	[152]
Dibenzopyran HU-210	Highly potent CB1-R and CB2-R agonist. Preference for CB1-R receptors.	[153]
Naphthylmethylindole JWH-175	Selective CB1-R agonist.	[154]
Phenylacetylindole JWH-250	Potent CB agonist with greater affinity towards CB1-R.	[155]