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. 2022 Oct 28;23(21):13108. doi: 10.3390/ijms232113108

Figure 2.

Figure 2

Fundus photography, OCT, and ERG of wild-type and Cyp4v2 KO mice. (A). Fundus images and OCT of retina in 5-month-old wild-type mouse. (B). Representative fundus image and OCT of 5-month-old KO mouse. (C). Representative fundus image of 10-month-old KO mouse, showing a retinal scar consistent with BCD. (D). OCT image of the KO mouse shown in (B) demonstrates hyperreflective spots in IS/OS of the photoreceptors in knock-out mice, as indicated by the arrow (E). OCT image of the KO mouse from (C) shows a retinal scar, as indicated by the arrow (F). Fluorescent angiogram of the mice shown in (C) and (E) demonstrates possible choroidal neovascularization below the scar. (G) Representative fundus images showing retinal crystals becoming less prominent with age. (H) Scotopic and photopic ERGs of 13-month-old knockout mice (N = 14) compared to wild type (N = 16).