Table 1.

The CYP2D activity and protein level after lurasidone treatment in the brain structures and liver.

Tissue		CYP2D Activity (% of Control)	CYP2D Protein Level (% of Control)
Brain structures	FCx	77 ± 6.7 ↓ *	84.5 ± 4.8 ↓ *
	St	131 ± 15.3 ↑ **	157.2 ± 10.8 ↑ *
	NA	175.3 ± 42.9 ↑ *	131.8 ± 11.2
	Hp	88.9 ± 16.7	96.4 ± 16.4
	Ht	99.7 ± 10.4	66.9 ± 4.6 ↓ *
	BS	133.9 ± 17.4 ↑ *	128.9 ± 8.9 ↑ *
	SN	154.5 ± 35.9 ↑ *	131.5 ± 5.1 ↑ *
	Cb	98.7 ± 23.3	92.2 ± 12.4
	RM	115.9 ± 15.8 ↑ *	122.4 ± 11.1 ↑ *
Liver		106.1 ± 28.6	106.6 ± 6.7

↑, ↓ Increase or decrease, respectively. Student’s t-test: * p < 0.05 vs. control group; ** p < 0.01 vs. control group. FCx—the frontal cortex, St—the striatum, NA—the nucleus accumbens, Hp—the hippocampus, Ht—the hypothalamus, BS—the brain stem, SN—the substantia nigra, Cb—the cerebellum, and RM—the remainder.