Table 4.
Specific information of three candidate apaQTLs in the screening and validation phase.
| Histology Type | SNPs | Phase | Genotypes | Cases, N (100%) | Controls, N (100%) | Adjusted OR (95% CI) a | p a |
|---|---|---|---|---|---|---|---|
| LUAD | rs10138506 | Screening | AA | 3048 (88.27) | 3324 (89.60) | 1 (ref) | -- |
| CHURC1 | AG | 390 (11.30) | 380 (10.24) | 1.12 (0.97–1.30) | 0.133 | ||
| GG | 15 (0.43) | 6 (0.16) | 2.72 (1.05–7.02) | 0.038 | |||
| Dominant model | 2.69 (1.04–6.94) | 0.041 | |||||
| Recessive model | 1.14 (0.99–1.32) | 0.071 | |||||
| Additive model | 1.16 (1.01–1.33) | 0.034 | |||||
| Validation | AA | 489 (84.90) | 591 (89.01) | 1 (ref) | -- | ||
| AG | 86 (14.93) | 72 (10.84) | 1.45 (1.03–2.03) | 0.033 | |||
| GG | 1 (0.17) | 1 (0.15) | 1.06 (0.07–17.00) | 0.969 | |||
| Dominant model | 1.44 (1.03–2.02) | 0.034 | |||||
| Additive model | 1.42 (1.02–1.98) | 0.038 | |||||
| LUSC | rs1130698 | Screening | TT | 493 (75.38) | 2915 (78.57) | 1 (ref) | -- |
| CD151 | TC | 149 (22.78) | 742 (20.00) | 1.19 (0.98–1.44) | 0.087 | ||
| CC | 12 (1.84) | 53 (1.43) | 1.39 (0.75–2.56) | 0.295 | |||
| Dominant model | 1.34 (0.73–2.46) | 0.351 | |||||
| Recessive model | 1.20 (0.99–1.45) | 0.060 | |||||
| Additive model | 1.19 (1.00–1.41) | 0.049 | |||||
| Validation | TT | 153 (75.37) | 535 (80.21) | 1 (ref) | -- | ||
| TC | 47 (23.15) | 126 (18.89) | 1.36 (0.91–2.02) | 0.138 | |||
| CC | 3 (1.48) | 6 (0.90) | 1.46 (0.33–6.48) | 0.615 | |||
| Dominant model | 1.36 (0.92–2.02) | 0.125 | |||||
| Additive model | 1.32 (0.92–1.90) | 0.130 | |||||
| LUSC | rs1130719 | Screening | AA | 455 (69.57) | 2751 (74.15) | 1 (ref) | -- |
| CD151 | AT | 175 (26.76) | 882 (23.77) | 1.20 (1.00–1.45) | 0.052 | ||
| TT | 24 (3.67) | 77 (2.08) | 1.86 (1.18–2.95) | 0.008 | |||
| Dominant model | 1.78 (1.13–2.81) | 0.014 | |||||
| Recessive model | 1.25 (1.05–1.50) | 0.012 | |||||
| Additive model | 1.26 (1.08–1.48) | 0.002 | |||||
| Validation | AA | 147 (72.41) | 482 (73.59) | 1 (ref) | -- | ||
| AT | 49 (24.14) | 154 (23.51) | 1.17 (0.79–1.73) | 0.428 | |||
| TT | 7 (3.45) | 19 (2.90) | 1.28 (0.50–3.26) | 0.611 | |||
| Dominant model | 1.18 (0.81–1.72) | 0.378 | |||||
| Additive model | 1.15 (0.84–1.58) | 0.372 | |||||
a Logistic regression analysis adjusted for age, gender and smoking status.