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. 2022 Oct 22;23(21):12729. doi: 10.3390/ijms232112729

Figure 7.

Figure 7

AdipoRon inhibits NPC tumor metastasis in vivo. (A) Bioluminescent (upper) and lung (lower) images from 5-8F-luc cells’ lung metastasis model after oral administration of AdipoRon (50 mg/kg/d) or vehicle (n = 7 per group). The black arrows indicate metastatic tumors. (B) Quantification of in vivo bioluminescent images (photon/s of lung region). (C) Wet lungs were counted and summarized. (D) Representative H and E staining of lung section. The black arrows indicate metastatic tumors. (E) The number of lung metastases were counted and summarized. Scale bar: 200 μm. (F) Immunohistochemistry of p-p65 and p-STAT3 protein levels in metastatic 5-8F-luc cells from the lung (n = 6). Scale bar: 100 μm. Quantification of protein expression in metastatic 5-8F-luccells. Results are presented as mean ± SD of three independent experiments performed in triplicate. * p < 0.05, ** p < 0.01.