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Graphic abstract of molecular mechanisms of laminA/C-regulated EMT promoting acquired resistance to erlotinib in NSCLC. LaminA/C inhibited the phosphorylation of AKT and FGFR to prevent cell proliferation of erlotinib-resistant cells. Meanwhile, laminA/C decreased ERK1/2 and c-fos activation and decreased vimentin and ZEB1 expressions, resulting in reversing of the process of EMT and improving of erlotinib sensitivity in NSCLC with EGFR mutation. By Figdraw (www.figdraw.com).
