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The 2.4Å structure of a Zn2+–bound precursor LOXL2 (PDB: 5ZE3). (A) The amine oxidase domain of LOXL2 and precursor residues (Lys653 and Tyr689 in magenta) of the LTQ cofactor and Zn2+ (navy sphere) occupies the predicted Cu2+–binding site, His626–X–His628–X–His630 motif (in green). (B) Lys653 is located 16.6Å distance from Tyr689 (in solid grey line). Zn2+ is in tetrahedral coordination geometry.
