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Electrostatic potential on the surface of the 3D–modeled catalytic domain of the resting form of LOXL2 (A), 2HP–inhibited LOXL2 (B) and the crystal structure of the Zn2+–bound precursor LOXL2 (C). LTQ, LTQ–2HP and Tyr689 (all in cyan) are exposed to the solvent. The acidic groove surrounding the LTQ cofactor and Cu2+ most likely accommodates substrate (Lys–containing peptides) binding.
