Table 2.
Sex-specific differences, and trends of subjects by eGFR category.
| eGFR Category (mL/min/1.73 m2) |
p for Difference |
SS ‡ |
p for Trend ‡ |
|||
|---|---|---|---|---|---|---|
| A | B | C | ||||
| Male, n | 2594 | 690 | 195 | |||
| eGFR, mg/dL † | 81.5 ± 15.8 (80.8, 82.1) |
54.1 ± 4.2 (53.8, 54.4) |
36.6 ± 8.4 (35.4, 37.8) |
A > B > C | −46.75 | <0.001 |
| Z score of VAI † | −0.06 ± 0.97 (−0.10, −0.03) |
0.15 ± 1.05 (0.07, 0.23) |
0.35 ± 1.05 (0.20, 0.50) |
A < B < C | 8.25 | <0.001 |
| Z score of BMI | −0.02 ± 1.01 (−0.06, 0.02) |
0.03 ± 0.97 (−0.04, 0.10) |
0.18 ± 0.98 (0.04, 0.31) |
A < C | 2.78 | <0.01 |
| Age, year | 69.4 ± 6.3 (69.2, 69.7) |
70.5 ± 6.2 (70.0, 71.0) |
70.6 ± 6.6 (69.7, 71.5) |
A < B < C | 4.47 | <0.001 |
| Height, cm † | 157.2 ± 8.3 (156.9, 157.6) |
164.5 ± 8.1 (163.9, 165.1) |
162.9 ± 8.2 (161.7, 164.0) |
A < B, A < C, B > C | 20.19 | <0.001 |
| Body mass, kg | 59.8 ± 9.9 (59.4, 60.1) |
65.9 ± 10.3 (65.1, 66.6) |
65.8 ± 10.3 (64.4, 67.3) |
A < B, C | 15.37 | <0.001 |
| WC, cm | 84.7 ± 9.1 (84.3, 85.0) |
87.7 ± 8.6 (87.1, 88.3) |
89.8 ± 8.8 (88.6, 91.1) |
A < B < C | 10.60 | <0.001 |
| Cre, mg/dL † | 0.75 ± 0.12 (0.74, 0.75) |
1.06 ± 0.08 (1.05, 1.07) |
1.67 ± 0.85 (1.55, 1.79) |
A < B < C | 46.52 | <0.001 |
| TG, mg/dL | 130.5 ± 75.1 (127.6, 133.4) |
137.0 ± 73.9 (131.5, 142.5) |
142.0 ± 62.8 (133.1, 150.9) |
NS | 4.15 | <0.001 |
| HDLC, mg/dL | 50.0 ± 12.0 (49.6, 50.5) |
46.3 ± 11.3 (45.5, 47.2) |
43.1 ± 10.5 (41.6, 44.6) |
A < B < C | −10.08 | <0.001 |
| Female, n | 1482 | 1677 | 1098 | |||
| eGFR, mg/dL † | 70.2 ± 8.6 (69.8, 70.7) |
52.3 ± 4.3 (52.1, 52.5) |
38.2 ± 5.8 (37.8, 38.5) |
A > B > C | −68.56 | <0.001 |
| Z score of VAI † | −0.15 ± 0.93 (−0.20, −0.10) |
−0.01 ± 0.99 (−0.05, 0.04) |
0.21 ± 1.07 (0.14, 0.27) |
A < B < C | 9.78 | <0.001 |
| Z score of BMI † | −0.01 ± 1.04 (−0.06, 0.04) |
−0.04 ± 1.00 (−0.09, 0.01) |
0.07 ± 0.94 (0.02, 0.13) |
A, B < C | 2.48 | <0.05 |
| Age, year | 69.3 ± 6.4 (69.0, 69.6) |
70.0 ± 6.5 (69.6, 70.3) |
70.1 ± 6.4 (69.8, 70.5) |
A < B, C | 3.50 | <0.001 |
| Height, cm † | 154.1 ± 6.5 (153.8, 154.4) |
159.7 ± 8.7 (159.2, 160.1) |
164.1 ± 7.8 (163.6, 164.5) |
A < B < C | 29.93 | <0.001 |
| Body mass, kg † | 57.6 ± 8.7 (57.1, 58.0) |
61.6 ± 9.4 (61.1, 62.0) |
66.0 ± 9.6 (65.4, 66.5) |
A < B < C | 21.91 | <0.001 |
| WC, cm | 83.9 ± 8.7 (83.4, 84.3) |
85.4 ± 8.6 (85.0, 85.8) |
88.3 ± 8.5 (87.8, 88.8) |
A < B < C | 12.81 | <0.001 |
| Cre, mg/dL † | 0.64 ± 0.06 (0.64, 0.64) |
0.83 ± 0.07 (0.83, 0.83) |
1.14 ± 0.41 (1.12, 1.17) |
A < B < C | 68.08 | <0.001 |
| TG, mg/dL | 126.4 ± 64.3 (123.1, 129.6) |
130.2 ± 64.5 (127.1, 133.3) |
135.3 ± 64.5 (131.5, 139.1) |
A < C | 4.21 | <0.001 |
| HDLC, mg/dL | 51.6 ± 11.9 (51.0, 52.2) |
49.2 ± 11.8 (48.6, 49.8) |
46.0 ± 11.3 (45.3, 46.6) |
A > B > C | −12.55 | <0.001 |
Values are means ± SD (95% CI). † Mann–Whitney U test was applied to assess the difference between groups. ‡ Jonckheere–Terpstra test was used to assess the trend among three groups. A = eGFR ≥ 60 (95% CI); B = eGFR 45–59.9 (95% CI); C = eGFR < 45 (95% CI); Cre = Creatinine eGFR = estimated glomerular filtration rate; TG = Triglyceride; VAI = visceral adiposity index; BMI = body mass index; HDLC = high density lipoprotein cholesterol; SS = standardized statistic; NS = not significant; WC = Waist circumference.