Figure 1.

Angiopoeitin-2 secretion is reduced in Rosiglitazone-treated preeclamptic placentas. Angiopoeitin-2 (Ang-2) levels were measured via Luminex assay from conditioned media from non-treated control and preeclamptic (PE) placentas (A) and vehicle- or Rosiglitazone (Rosi)-treated PE placentas (B). There was no significant difference in Ang-2 secretion between PE and control placentas (A, n > 10). Rosi-treated PE placentas show a significant reduction of Ang-2 secretion in comparison to the vehicle control (B, n = 14). (Protein secretion was measured by a Luminex assay where experimental values were determined relative to a standard curve. Statistical analysis was performed by student’s t-test to determine significant differences between groups, * p < 0.05, bar plots and data reported are reported as mean pg/mL values ± SEM).