Figure 3.

There are no significant differences in Endothelin-1 secretion from healthy or preeclamptic placentas with or without drug treatment. Secretion of Endothelin-1 was measured via Luminex assay from conditioned media from non-treated control and preeclamptic (PE) placentas (A) and vehicle- or Rosiglitazone (Rosi)-treated PE placentas (B). There was no significant change in ET-1 secretion between PE and control placentas (A, n > 10) and between vehicle and Rosi-treated PE placentas in the PE compared to control placentas however this was not statistically significant (B, n = 14). (Protein secretion was measured by a Luminex assay where experimental values were determined relative to a standard curve. Statistical analysis was performed by student’s t-test to determine significant differences between groups, bar plots and data reported are reported as mean pg/mL values ± SEM).