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LD50 of isogenic mutant strains
| Strain | LD50 (95% CI)a in:
|
|
|---|---|---|
| Cirrhotic rats | Control rats | |
| H+C+ | 2.5 × 106 (8.1 × 105–7.8 × 106) | 7.9 × 106 (1.4 × 106–4.6 × 107) |
| H+C− | 7.9 × 107 (1.4 × 107–4.0 × 108) | 3.2 × 107 (1.1 × 107–9.3 × 107) |
| PLY− | 7.9 × 107 (7.9 × 106–7.9 × 108) | >7.9 × 107b |
The results are expressed as the 50% lethal dose with 95% confidence intervals (CI) (as determined by the method of Litchfield and Wilcoxon [17]).
No deaths recorded at any of the doses used.
