Fig. 1.
WGS identifies disruption of Pi3k/Akt/mTOR signaling in Trp53R245W/+ breast tumors. (A) The graph showing exonic mutation count for each tumor. Types of mutations were also shown. A total of nine tumors were sequenced. (B) A graph depicting distribution of exonic mutations on different chromosomes for each tumor. (C) GO enrichment analysis of the mutated genes identified in Trp53R245W/+ tumors. GTPase, guanosine triphosphatase. (D) The identified cancer genes in our mouse tumors were input into cBioPortal to generate OncoPrint for these genes in TP53-mutant human breast tumors (n = 280) in The Cancer Genome Atlas data. All identified cancer genes in mouse tumors were altered in TP53-mutant human breast tumors to various extents.