TABLE 2.
Included articles.
| Author | Title | Year | Journal | Research field |
|---|---|---|---|---|
| Aalto-Setälä et al. | Obtaining consent for future research with induced pluripotent cells: opportunities and challenges | 2009 | PLoS Biology | Cell-Based Therapy |
| Afshar et al. | Ethics of research on stem cells and regenerative medicine: ethical guidelines in the Islamic Republic of Iran | 2020 | Stem Cell Research & Therapy | Regenerative Medicine |
| No Author | European Medicines Agency, CAR Secretariat and US Food and Drug Administration | 2011 | Regenerative Medicine | Cell-Based Therapy |
| Apatoff et al. | Autologous stem cell therapy for inherited and acquired retinal disease | 2017 | Regenerative Medicine | Cell-Based Therapy |
| Attico et al. | Approaches for effective clinical application of stem cell transplantation | 2018 | Current Transplantation Reports | Cell-Based Therapy |
| Baker et al. | Ethical considerations in Tissue Engineering Research: case Studies in Translation | 2016 | Methods | Tissue Engineering |
| Bhangra et al. | Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair | 2016 | Stem Cells International | Cell-Based Therapy |
| Bliss et al. | Optimizing the Success of Cell Transplantation Therapy for stroke | 2010 | Neurobiology of Disease | Cell-Based Therapy |
| Bobba et al. | The current state of stem cell therapy for ocular disease | 2018 | Experimental Eye Research | Cell-Based Therapy |
| Bredenoord et al. | Human tissues in a dish: The research and ethical implication of organoid technology | 2017 | Science | Organoid Transplantation |
| Brignier et al. | Embryonic and adult stem cell therapy | 2010 | Journal of Allergy and Clinical Immunology | Cell-Based Therapy |
| Chan. | Current and emerging global themes in the bioethics of regenerative medicine: the tangled web of stem cell translation | 2017 | Regenerative Medicine | Cell-Based Therapy |
| Chan. | Research Translation and Emerging Health Technologies: Synthetic Biology and Beyond | 2018 | Health Care Anal | Synthetic Biology |
| Chung | Stem-cell-based Therapy in the field of urology: a review of stem cell basic science, clinical application and future directions in the treatment of various sexual and urinary conditions | 2015 | Expert Opinion in Biological Therapy | Cell-Based Therapy |
| Coombe et al. | Current approaches in regenerative medicine for the treatment of diabetes: introducing CRISPR/CAS9 technology and the case for non-embryonic stem cell therapy | 2018 | American Journal Stem Cells | Cell-Based Therapy |
| Court et al. | Bioartificial liver support devices: historical perspectives | 2003 | ANZ Journal of Surgery | Bioengineered Organs |
| Daley et al. | Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines | 2016 | Stem Cell Reports | Cell-Based Therapy |
| Davis et al. | The role of Stem Cells for Reconstructing the Lower Urinary Tracts | 2018 | Current Stem cell Research & Therapy | Cell-Based Therapy |
| Davidson. | Brave Pioneers or Clinical Cowboys? | 2010 | Cell Stem Cell | Cell-Based Therapy |
| De Vries et al. | Ethical Aspects of Tissue Engineering: A Review | 2008 | Tissue engineering | Tissue Engineering |
| De Windt et al. | Ethics in musculoskeletal regenerative medicine; guidance in choosing the appropriate comparator in clinical trials | 2019 | Osteoarthritis and Cartilage | Regenerative Medicine |
| Fears et al. | Inclusivity and diversity: Integrating international perspectives on stem cell challenges and potential | 2021 | Stem Cell Reports | Cell-Based Therapy |
| Fung et al. | Responsible Translation of Stem Cell Research: An Assessment of Clinical Trial Registration and Publications | 2017 | Stem Cell Reports | Cell-Based Therapy |
| Garg et al. | Stem Cell Therapies in Retinal Disorders | 2017 | Cells | Cell-Based Therapy |
| Genske et al. | Rethinking risk assessment for emerging technology first-in-human trials | 2016 | Medicine, Health Care and Philosophy | Synthetic Biology |
| Giancola et al. | Cell therapy: cGMP Facilities and manufacturing | 2012 | Muscles, Ligaments and Tendons Journal | Cell-Based Therapy |
| Gilbert et al. | Print Me an Organ? Ethical and Regulatory Issues Emerging from 3D Bioprinting in Medicine | 2018 | Science and Engineering Ethics | 3D Bioprinting |
| Goula et al. | Advanced Therapy Medicinal Products Challenges and Perspectives in Regenerative Medicine | 2020 | Journal of Clinical Medicine Research | Regenerative Medicine |
| Haake et al. | Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood Cells- Ready for Take-Off | 2019 | Stem Cells Translational Medicine | Cell-Based Therapy |
| Habets et al. | The inherent ethical challenge of first-in-human pluripotent stem cell trials | 2014 | Regenerative Medicine | Cell-Based Therapy |
| Hara et al. | New Governmental Regulatory System for Stem Cell-Based Therapies in Japan | 2014 | Therapeutic Innovation & Regulatory Science | Cell-Based Therapy |
| Hayakawa et al. | A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of allogeneic human somatic stem cells | 2015 | Regenerative Therapy | Cell-Based Therapy |
| Hildebrandt | Horses for courses: an approach to the qualification of clinical trial sites and investigators in ATMPs | 2020 | Drug Discovery Today | Cell-Based Therapy |
| Hug | Understanding voluntariness of consent in first-in-human cell therapy trials | 2020 | Regenerative Medicine | Cell-Based Therapy |
| Hyun | Allowing innovative Stem Cell-Based Therapies Outside of Clinical Trials: Ethical and Policy Challenges | 2010 | Journal of Law, Medicine and Ethics | Cell-Based Therapy |
| Hyun et al. | New ISSCR Guidelines Underscore Major Principles for Responsible Translational Stem Cell Research | 2008 | Cell Stem Cell | Cell-Based Therapy |
| Kim et al. | Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem cells | 2017 | Stem Cells Translational Medicine | Cell-Based Therapy |
| King et al. | Ethical issues in stem cell research and therapy | 2014 | Stem Cell Research & Therapy | Cell-Based Therapy |
| Kleiderman et al. | Overcoming barriers to facilitate the regulation of multi-centre regenerative medicine clinical trials | 2018 | Stem Cell Research & Therapy | Regenerative Medicine |
| Knoepfler | From Bench to FDA to Bedside: US Regulatory Trends for New Stem Cell Therapies | 2015 | Advanced Drug Delivery Reviews | Cell-Based Therapy |
| Kusunose et al. | Informed consent in clinical trials using stem cells: Suggestions and points of attention from informed consent training workshops in Japan | 2015 | South African Journal of Bioethics and Law | Cell-Based Therapy |
| Lederer et al. | Neural stem cells: mechanisms of fate specification and nuclear reprogramming in regenerative medicine | 2008 | Biotechnology Journal | Cell-Based Therapy |
| Lee et al. | Conditional approvals for autologous stem cell-based interventions | 2018 | Perspectives in Biology and Medicine | Cell-Based Therapy |
| Levin et al. | Special Commentary: early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative | 2017 | Ophthalmology | Cell-Based Therapy |
| Lim et al. | Whole Organ and Tissue Reconstruction in Thoracic Regenerative Surgery | 2013 | Mayo clinic Proceedings | Tissue Engineering |
| Liras | Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects | 2010 | Journal of translational Medicine | Cell-Based Therapy |
| Liu et al. | Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, And Applications§ | 2020 | Stem Cell Reviews and Reports | Cell-Based Therapy |
| Lomax et al. | Return of results in translational iPS cell research: considerations for donor informed consent | 2013 | Stem Cell Research & Therapy | Cell-Based Therapy |
| Lomax et al. | Regulated, reliable and reputable: Protect patients with uniform standards for stem cell treatments | 2020 | Stem Cells Translational Medicine | Cell-Based Therapy |
| Lowenthal et al. | Specimen Collection for Induced Pluripotent Stem Cell Research: Harmonizing the Approach to Informed Consent | 2012 | Stem Cells Translational Medicine | Cell-Based Therapy |
| Lowenthal et al. | Ethics and Policy Issues for Stem Cell Research and Pulmonary Medicine | 2014 | Chest | Cell-Based Therapy |
| Lu et al. | Tissue Engineered Constructs: Perspectives on Clinical Translation | 2015 | Annals of Biomedical Engineering | Tissue Engineering |
| Madariaga et al. | Bioengineering Kidneys for Transplantation | 2014 | Seminars in Nephrology | Bioengineered Organs |
| Maekawa et al. | Development of Novel Advanced Cell and Gene Therapy and GMP-Controlled Cell Processing | 2005 | Japan Medical Association journal | Cell-Based Therapy |
| Main et al. | Managing the potential and pitfalls during clinical translation of emerging stem cell therapies | 2014 | Clinical and Translational Medicine | Cell-Based Therapy |
| Masuda et al. | New Challenges for Intervertebral Disc Treatment Using Regenerative Medicine | 2010 | Tissue engineering | Regenerative Medicine |
| Moradi et al. | Research and therapy with induced pluripotent stem cells (iPSCs): Social, legal and ethical considerations | 2019 | Stem Cell Research & Therapy | Cell-Based Therapy |
| Nagamura | The Importance of Recruiting a Diverse Population for Stem Cell Clinical Trials | 2016 | Current Stem Cell Reports | Cell-Based Therapy |
| Naghieh et al. | Biofabrication Strategies for Musculoskeletal Disorders: Evolution towards Clinical Application | 2021 | Bioengineering | 3D Bioprinting |
| Nagpal et al. | PERSPECTIVES: Stroke survivors’ views on the design of an early‐phase cell therapy trial for patients with chronic ischaemic stroke | 2019 | Health Expectations | Cell-Based Therapy |
| Neri | Genetic Stability of Mesenchymal Stromal Cells for Regenerative Medicine Applications: A Fundamental Biosafety Aspect | 2019 | International Journal of Molecular Sciences | Cell-Based Therapy |
| Niemansburg et al. | Participant selection for preventive Regenerative Medicine trials: ethical challenges of selecting individuals at risk | 2015 | Journal of Medical ethics | Regenerative Medicine |
| Niemansburg et al. | Regenerative medicine interventions for orthopedic disorders: ethical issues in the translation into patient | 2013 | Regenerative Medicine | Regenerative Medicine |
| Niemansburg et al. | Ethical implications of regenerative medicine in orthopedics: an empirical study with surgeons and scientists in the field | 2014 | The spine Journal | Regenerative Medicine |
| O’Donnell et al. | Beyond the Present Constraints That Prevent a Wide Spread of Tissue Engineering and Regenerative Medicine Approaches | 2019 | Frontiers Bioengineering and Biotechnology | Regenerative Medicine |
| Oerlemans et al. | Regenerative Urology Clinical Trials: An Ethical Assessment of Road Blocks and Solution | 2013 | Tissue engineering | Tissue Engineering |
| Oerlemans et al. | Towards a Richer Debate on Tissue Engineering: A Consideration on the Basis of NEST-Ethics | 2012 | Science Engineering Ethics | Tissue Engineering |
| O’Keefe | American Society for Bone and Mineral Research- Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies | 2020 | Journal of Bone and Mineral Research | Cell-Based Therapy |
| Otto et al. | Ethical considerations in the translation of biofabrication technologies into clinic and society | 2016 | Biofabrication | 3D Bioprinting |
| Parent et al. | The ethics of testing and research of manufactured organs on brain-dead/recently deceased subjects | 2019 | Journal of Medical Ethics | Bioengineered Organs |
| Patuzzo et al. | 3D bioprinting Technology: Scientific Aspects and Ethical Issues | 2018 | Science and Engineering Ethics | 3D Bioprinting |
| Schneemann et al. | Ethical challenges for pediatric liver organoid transplantation | 2020 | Science Translational Medicine | Organoid Transplantation |
| Scopetti et al. | Mesenchymal stem cells in neurodegenerative diseases: Opinion review on ethical dilemmas | 2020 | World Journal of Stem Cells | Cell-Based Therapy |
| Sekar et al. | Current standards and ethical landscape of engineered issues—3D bioprinting perspective | 2021 | Journal of Tissue Engineering | 3D Bioprinting |
| Seok et al. | A Personalized 3D-Printed Model for Obtaining Informed | 2021 | Journal of Personalized Medicine | 3D Bioprinting |
| Consent Process for Thyroid Surgery: A Randomized Clinical Study Using a Deep Learning Approach with Mesh-Type 3D Modeling | ||||
| Shineha et al. | A Comparative Analysis of Attitudes on Communication Toward Stem Cell Research and Regenerative Medicine Between the Public and the Scientific Community | 2018 | Stem Cells Translational Medicine | Regenerative Medicine |
| Sievert et al. | Tissue Engineering for the Lower Urinary Tract: A Review of a State of the Art Approach | 2007 | European Urology | Tissue Engineering |
| Smith et al. | Challenging misinformation and engaging patients: characterizing a regenerative medicine consult service | 2020 | Regenerative Medicine | Regenerative Medicine |
| Sniecinski et al. | Emerging stem cell based strategies for treatment of childhood disease | 2018 | Transfusion and Apheresis Science | Cell-Based Therapy |
| Stegemann et al. | Cell therapy for bone repair: narrowing the gap between vision and practice | 2014 | European Cells and Materials | Cell-based therapy |
| Sugarman and Bredenoord | Real-time ethics engagement in biomedical research | 2020 | EMBO reports | Organoid transplantation |
| Sutherland and Mayer | Ethical and Regulatory Issues Concerning Engineered Tissues for Congenital Heart Repair | 2003 | Thoracic and Cardiovascular Surgery | Tissue Engineering |
| Takashima et al. | Lessons for reviewing clinical trials using induced pluripotent stem cells: examining the case of a first-in-human trial for age-related macular degeneration | 2018 | Regenerative Medicine | Cell-Based Therapy |
| Taylor et al. | Ethics of bioengineering organs and tissues | 2014 | Expert Opinion on Biological Therapy | Tissue Engineering |
| Trommelmans et al. | Ethical reflections on clinical trials with human tissue engineered products | 2008 | Journal of Medical Ethics | Tissue Engineering |
| Trommelmans et al. | Informing participants in clinical trials with ex vivo human tissue-engineered products: what to tell and how to tell it? | 2008 | Journal Tissue Engineering Regenerative Medicine | Tissue Engineering |
| Trommelmans et al. | An Exploratory Survey on the Views of European Tissue Engineers Concerning the Ethical Issues of Tissue Engineering Research | 2009 | Tissue Engineering | Tissue Engineering |
| Trommelmans et al. | Is tissue engineering a new paradigm in medicine? Consequences for the ethical evaluation of tissue engineering research | 2009 | Medical Health Care and Philosophy | Tissue Engineering |
| Tsang | Legal and ethical status of stem cells as medicinal products | 2005 | Advanced Drug Delivery | Cell-Based Therapy |
| Vijayavenkataraman et al. | 3D bioprinting - An Ethical, Legal and Social Aspects (ELSA) framework | 2016 | Bioprinting | 3D Bioprinting |
| Zamborsky et al. | Regenerative Medicine in Orthopaedics and Trauma: Challenges, Regulation and Ethical Issues | 2018 | Orthopaedics and Trauma | Cell-Based Therapy |
| Zocchi et al. | Regulatory, ethical, and technical considerations on regenerative technologies and adipose-derived mesenchymal stem cells | 2019 | European Journal of Plastic Surgery | Regenerative Medicine |
a
Author name stated in bold: ethical considerations for early-phase regenerative trials are elaborately discussed in the paper.