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. 2022 Oct 31;9:1027758. doi: 10.3389/fmed.2022.1027758

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Copyright © 2022 Shadbad, Ghorbaninezhad, Hassanian, Ahangar, Hosseinkhani, Derakhshani, Shekari, Brunetti, Silvestris and Baradaran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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has_circ_0002476/hsa-miR-216a-5p/PD-L1 and hsa_circ_0063526/hsa-miR-1299/PD-L1 might increase programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC). (A–C) Normalizing, clustering, and identifying differentially expressed circRNAs from the GSE158695 dataset. (D–F) Normalizing, clustering, and identifying differentially expressed circRNAs from the GSE63805 dataset. (G) Identifying the commonality between the miR targets of upregulated circRNAs in NSCLC tissues between the downregulated miRs in NSCLC tissues. (H) Identifying which of those miRs can target PD-L1 based on the microT-CDS database.