TABLE 2.
Fold increases in CTB-specific IgA and IgG responses in serum, BAL fluid, and urine after nasal vaccination
| Isotype | Sample | Response frequency (no. of responders/ total no.)a | Geometric mean fold increaseb for:
|
P for all subjectsc | |
|---|---|---|---|---|---|
| All subjects | Responders | ||||
| IgA | Serum | 8/9 | 10.6 | 13.4 | 0.0009 |
| BAL fluid | 6/9 | 3.1 | 5.5 | 0.009 | |
| Urine | 4/8d | 3.1 | 10.2 | 0.04 | |
| IgG | Serum | 8/9 | 11.0 | 13.9 | 0.0001 |
| BAL fluid | 9/9 | 8.2 | 8.2 | 0.001 | |
| Urine | 5/8 | 2.6 | 5.9 | 0.09 | |
a
Responders were defined as having a greater than twofold increase in titer.
b
The fold increases for all samples except serum are calculated from the titers adjusted for the total Ig content in the sample.
c
Statistical significance of titer increases obtained by using the paired Student t test.
d
One urine sample was inadvertently destroyed.