TABLE 3.
Fold increases in CTB-specific IgA and IgG responses in serum, BAL fluid, and urine after oral vaccination
| Isotype | Sample | Response frequency (no. of responders/ total no.)a | Geometric mean fold increaseb for:
|
P for all subjectsc | |
|---|---|---|---|---|---|
| All subjects | Responders | ||||
| IgA | Serum | 4/6 | 8.6 | 13.2 | 0.01 |
| BAL fluid | 2/6 | 1.6 | 3.5 | 0.2 | |
| Urine | 2/6 | 2.5 | 9.4 | 0.1 | |
| IgG | Serum | 4/6 | 3.8 | 8.0 | 0.08 |
| BAL fluid | 3/6 | 3.0 | 9.2 | 0.1 | |
| Urine | 3/6 | 3.0 | 8.6 | 0.09 | |
a
Responders were defined as having a greater than twofold increase in titer.
b
The fold increases for all samples except serum are calculated from the titers adjusted for the total Ig content in the sample.
c
Statistical significance of titer increases obtained by using the paired Student t test.