TABLE 7.
Cox Regression analysis to assess the risk of kidney allograft loss in KTRs 20 years post-transplantation.
| Univariate Cox regression | HR | 95% CI | p-Value |
|---|---|---|---|
| Group (Group 2) | 11.533 | 3.533–37.650 | < 0.001 |
| 20-year eGFR (BSA-deindexed CKD-EPI) | 0.926 | 0.906–0.947) | < 0.001 |
| 20-year proteinuria | 1.001 | 1.000–1.001 | < 0.001 |
| eGFR (CKD-EPI) decline | 0.786 | 0.703–0.879 | < 0.001 |
| Time on pretransplant dialysis (per month) | 0.995 | 0.979–1.012 | 0.581 |
| Pretransplant dialysis a (PD) | 0.664 | 0.311–1.419 | 0.291 |
| HLA Mismatch (per mismatch) | 0.907 | 0.686–1.199 | 0.492 |
| DSA (DSA-positive) | 2.719 | 1.081–6.841 | 0.034 |
| Donation after cardiac death (DCD) | 1.684 | 0.484–5.882 | 0.413 |
| Donor sex (male) | 1.790 | 0.936–3.424 | 0.078 |
| Donor Age (per year) | 1.043 | 1.021–1.065 | < 0.001 |
| Retransplantation (retransplant) | 2.094 | 0.926–4.738 | 0.076 |
| GN b as the cause of ESKD (all other) | 1.463 | 0.785–2.725 | 0.231 |
| Transplant era (1981–1989) | 0.836 | 0.414–1.691 | 0.619 |
| BMI 20 years post-transplant | 0.973 | 0.904–1.047 | 0.458 |
| HbA1c 20 years post-transplant | 1.246 | 0.770–2.016 | 0.37 |
| CSA-based immunosuppression (CsA-free) | 0.794 | 0.394–1.598 | 0.518 |
| steroid-containing immunosuppression (steroids) | 2.572 | 1.382–4.787 | 0.003 |
| Early TCMR (<12 months) | 1.847 | 0.905–3.771 | 0.092 |
| Multivariate Cox Regression | |||
| Group (Group 2) | 20.515 | 2.730–154.143 | 0.003 |
| DSA (DSA-positive) | 3.081 | 1.165–8.146 | 0.023 |
| Donor age (per year) | 1.032 | 1.004–1.061 | 0.024 |
| Steroid-containing immunosuppression (steroids) | 2.844 | 1.295–6.246 | 0.009 |
a
Only HD vs. PD/HD.
b
Glomerulonephritis, incl. vasculitis, systemic lupus erythematosus, and suspected chronic GN.
Univariable and multivariable Cox regression models for death-censored graft failure. Reference category in parentheses. HR, hazard ratio; CI, confidence interval.