TABLE 8.
Cox Regression analysis to assess the mortality risk of KTRs 20 years post-transplantation.
| Univariate Cox regression analysis | HR | 95% CI | p-Value |
|---|---|---|---|
| Group (Group 2) | 1.301 | 0.749–2.261 | 0.350 |
| 20-year eGFR (BSA deindexed CKD-EPI) | 0.995 | 0.981–1.009 | 0.469 |
| 20-year proteinuria | 1.000 | 1.000–1.001 | < 0.001 |
| eGFR (CKD)-EPI) decline | 1.071 | 0.949–1.208 | 0.266 |
| Recipinet sex (male) | 1.742 | 1.013–2.995 | 0.045 |
| Recipient age (per year) | 1.084 | 1.054–1.115 | < 0.001 |
| Time on pretransplant dialysis (per month) | 1.003 | 0.992–1.014 | 0.616 |
| Pretransplant dialysis a (PD) | 0.645 | 0.335–1.241 | 0.189 |
| Retransplantation (retransplant) | 1.044 | 0.416–2.625 | 0.926 |
| GN 2 as the cause of ESKD (all other) | 0.456 | 0.244–0.854 | 0.014 |
| Transplant era (1981–1989) | 1.136 | 0.613–2.105 | 0.685 |
| BMI 20 years post-transplant | 0.989 | 0.929–1.053 | 0.730 |
| HbA1c 20 years post-transplant | 1.126 | 0.727–1.745 | 0.595 |
| CsA-based immunosuppression (CsA-free) | 0.372 | 0.214–0.645 | < 0.001 |
| containing steroid-containing immunosuppression (steroid-free) | 1.936 | 1.126–3.327 | 0.017 |
| Multivariate Cox regression analysis | |||
| Recipient sex (male) | 1.829 | 1.021–3.276 | 0.042 |
| Recipient age (per year) | 1.094 | 1.062–1.126 | < 0.001 |
| CSA-based immunosuppression (CsA-free) | 0.297 | 0.149–0.593 | < 0.001 |
| containing steroid-containing immunosuppression (steroid-free) | 1.701 | 0.866–3.340 | 0.123 |
| GN b as Cause for ESKD (all other) | 0.827 | 0.429–1.595 | 0.571 |
a
Only HD vs. PD/HD.
b
Glomerulonephritis, incl. vasculitis, systemic lupus erythematosus, and suspected chronic GN.
Univariable and multivariable Cox regression models for patient survival. Reference category in parentheses. HR, hazard ratio; CI, confidence interval.