Table 1.
Basic features of the publications included in this meta-analysis (n=18).
| Study | Year | Region | Sample size | Cancer type | Detection method | Sample | Cut-off | survival analysis | HR statistics | Hazard ratios(95% CI) | Follow-up (month) | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Xie M | 2015 | China | 55 | Gastric cancer | qRT-PCR | tissue | median | OS | indirectly | 6.45(1.92,21.63) | 50 | 7 |
| DFS | indirectly | 8.33(1.94,35.75) | ||||||||||
| Li Q | 2016 | China | 30 | CRC | qRT-PCR | tissue | median | OS | indirectly | 4.7(1.01, 21.87) | 28 | 7 |
| Ding J | 2017 | China | 69 | CRC | qRT-PCR | tissue | not reported | lack off | NA | - | NA | 6 |
| Wang F | 2016 | China | 112 | HCC | qRT-PCR | tissue | median | OS | indirectly | 1.96(1.17,3.28) | 80 | 7 |
| Zhang Y | 2018 | China | 58 | HCC | qRT-PCR | tissue | mean | lack off | NA | – | NA | 6 |
| Lu Q | 2020 | China | 116 | HCC | qRT-PCR | tissue | median | OS | directly | 2.76(1.115,6.848) | 25 | 9 |
| Wang Y | 2018 | China | 66 | Osteosar- coma |
qRT-PCR | tissue | median | lack off | NA | – | NA | 6 |
| Wang L | 2019 | China | 27 | Osteosar- coma |
qRT-PCR | tissue | mean | OS | indirectly | 0.75(0.16,3.45) | 60 | 7 |
| Wu L | 2019 | China | 50 | Glioma | qRT-PCR | tissue | not reported | lack off | NA | – | NA | 6 |
| Fang Y | 2017 | China | 38 | Breast cancer | qRT-PCR | tissue | not reported | OS | indirectly | 1.51(0.53, 4.27) | 90 | 7 |
| Li Y | 2017 | China | 103 | NSCLC | qRT-PCR | tissue | median | OS | directly | 6.711(3.526-17.019) | 75 | 9 |
| DFS | directly | 6.737(2.926-20.527) | ||||||||||
| Cui T J | 2019 | China | 40 | NSCLC | qRT-PCR | tissue | not reported | OS | indirectly | 1.70(0.29,10.48) | 75 | 8 |
| Xia F | 2018 | China | 128 | PTC | qRT-PCR | tissue | mean | lack off | NA | – | NA | 6 |
| Jiang L | 2019 | China | 68 | PTC | qRT-PCR | tissue | mean | OS | indirectly | 1.45(0.53, 3.98) | 60 | 7 |
| Wang F | 2019 | China | 80 | Bladder cancer | qRT-PCR | tissue | not reported | lack off | NA | – | NA | 6 |
| Xiao S | 2020 | China | 68 | Prostate cancer | qRT-PCR | tissue | mean | OS | indirectly | 1.55(0.2, 11.91) | 60 | 7 |
| ChenR (a) |
2021 | China | 46 | OSCC | qRT-PCR | tissue | not reported | lack off | NA | – | NA | 6 |
| ChenR (b) |
2021 | China | 27 | Cervical cancer | qRT-PCR | tissue | mean | OS | directly | 2.80(1.0, 7.9) | 120 | 8 |
CRC, colorectal cancer; HCC, hepatocellular carcinoma; NSCLC, non-small cell lung cancer; PTC, papillary thyroid cancer; OSCC, Oral Squamous Cell Carcinoma; NA, not available; qRT-PCR, quantitative reverse transcription-polymerase chain reaction; OS, overall survival; DFS, disease−free survival.