Table 3.
Regulation mechanism of HOXA-AS2 involved in various solid tumors.
| Cancer type | Expression | Micro-RNAs | Targets | Functions | References |
|---|---|---|---|---|---|
| NSCLC | up-regulation | miR-216a-5p | – | Proliferation, migration, invasion | Cui T J (19) |
| up-regulation | miR-520a-3p | HOXD8/MAP3K2 | cell proliferation, migration, invasion | Liu Y (58) | |
| up-regulation | miR-302a-3p | – | invasion, migration, proliferation | Pan X (21) | |
| up-regulation | - | IGF2 | invasion, migration | Zheng (20) | |
| Bladder cancer | up-regulation | miR-125b | Smad2 | migration, invasion, stemness | Wang F (30) |
| Prostate cancer | up-regulation | miR-5590-3p | PBX3 | EMT, proliferation, migration | Xiao S (31) |
| CRC | up-regulation | – | EZH2, LSD1 | cell proliferation, inhibit apoptosis | Ding J (29) |
| HCC | up-regulation | miR-520c-3p | GPC3 | cell proliferation, migration, invasion | Zhang Y (27) |
| hepatoblastoma | up-regulation | miR-217 | HOXA3 | proliferation, migration, invasion | Liu G (60) |
| Ovarian cancer | up-regulation | miR-520a-3p | – | proliferation,migration, invasion | Xie D (32) |
| Endometrial cancer | up-regulation | miR-302c-3p | ZFX,YKL-40 | proliferation, invasion | Song N (33) |
| Breast cancer | up-regulation | miR-520c-3p | TGFBR2, RELA | proliferation, invasion | Fang Y (18) |
| Cervical cancer | up-regulation | miR-509-3p | BTN3A1 | invasion, metastasis | Chen R (35) |
| up-regulation | – | Notch Pathway | cell proliferation, migration | Wu Q (34) | |
| Gastric cancer | up-regulation | – | P21/PLK3/DDIT3 | cell proliferation, tumorigenesis | Xie M (24) |
| Osteosarcoma | up-regulation | miR-520c-3p | – | EMT, migration, invasion | Wang Y (37) |
| up-regulation | miR-124-3p | E2F3 | migration, invasion | Wang L (36) | |
| Gallbladder carcinoma | up-regulation | – | E-cadherin | migration, invasion, EMT | Zhang P (23) |
| Glioma | up-regulation | miR-373 | EFGR | migration, invasion, vasculogenic mimicry | Gao Y (59) |
| up-regulation | – | RND3 | proliferation, invasion, inhibit apoptosis | Wu L (47) | |
| up-regulation | miR-184 | COL6A2 | cell proliferation | Chen P Y (61) | |
| up-regulation | – | E2F8,E2F1,ATF3 | proliferation,inflammation | Le Boiteux (56) | |
| up-regulation | miR-302a | KDM2A/JAG1 | T cell proliferation, immune tolerance | Zhong C (62) | |
| Glioblastoma | up-regulation | miR-885-5p | RBBP4 | cell proliferation | Shou J (38) |
| up-regulation | miR-2116-3p | SERPINA3 | proliferation, invasion, inhibit apoptosis | Sun J (39) | |
| Pancreatic cancer |
up-regulation | – | EZH2, LSD1 | cell proliferation | Lian Y (28) |
| NPC | up-regulation | miR-519 | PD-L1,HIF-1α | proliferation, migration, invasion | Wang S (63) |
| PTC | up-regulation | miR-520c-3p | S100A4 | migration, invasion | Xia F (16) |
| up-regulation | miR-15a-5p | HOXA3 | proliferation, migration, invasion | Jiang L (15) | |
| OSCC | up-regulation | miR-567 | CDK8 | cell proliferation | Chen R (13) |
| up-regulation | – | EZH2 | proliferation, migration, invasion | Zhao Z (12) |
NSCLC, non-small cell lung cancer; CRC, colorectal cancer; PTC, papillary thyroid cancer; NPC, nasopharyngeal carcinoma; OSCC, oral squamous cell carcinoma; HCC, hepatocellular carcinoma.