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. 2022 Oct 31;12:1037523. doi: 10.3389/fonc.2022.1037523

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Copyright © 2022 Zheng, Song, Wang, Zhang, Tang, Wang, Li, Wu, Song and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between plasma exosomal tRF-Ala-AGC-036 and tumor stage. (A) (B) Expression levels of exosomal tRF-Ala-AGC-036 in T and N stages NSCLC patients. (C) The expression level of exosomal tRF-Ala-AGC-036 of NSCLC patients with advanced stage (III-IV) was lower than that of NSCLC patients with early-stage (0- II). (D) Exosomal tRF-Ala-AGC-036 was downregulated in M1 stage NSCLC patients compared with M0 stage NSCLC patients. (E) ROC curve analysis of exosomal tRF-Ala-AGC-036 for M1 stage NSCLC patients relative to M0 stage NSCLC patients (*p < 0.05, **p < 0.01, ***p < 0.001).