TABLE 5.

Univariate and multivariate analysis of overall survival in ESCC patients stratified by gender after PSM.

Variables	Male (n = 483)				Female (n = 483)
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age (≤60 vs. > 60)	0.78 (0.59–1.03)	0.08			0.75 (0.55–1.04)	0.09
TNM stage (0/1/2 vs. 3/4)	0.27 (0.20–0.37)	<0.01	0.35 (0.25–0.48)	<0.01	0.27 (0.19–0.38)	<0.01	0.32 (0.22–0.45)	<0.01
Surgical margin (R0 vs. R1/R2)	0.76 (0.47–1.21)	0.24			0.72 (0.34–1.54)	0.40
Location (upper vs. middle, lower)	1.19 (0.91–1.55)	0.20			1.06 (0.78–1.44)	0.71
Vascular invasion (no vs. yes)	0.45 (0.32–0.63)	<0.01	0.60 (0.41–0.88)	0.01	0.40 (0.28–0.58)	<0.01	0.71 (0.48–1.05)	0.09
Neural invasion (no vs. yes)	0.65 (0.45–0.93)	0.02	0.95 (0.63–1.41)	0.78	0.43 (0.29–0.65)	<0.01	0.58 (0.38–0.87)	0.01
Tumor grade (moderate, poorly vs. well)	0.95 (0.73–1.24)	0.70			1.01 (0.74–1.36)	0.97
Postoperative adjuvant treatment (no vs. yes)	0.94 (0.72–1.23)	0.65			0.76 (0.56–1.03)	0.07
Tumor diameter (continuous)	1.14 (1.08–1.19)	<0.01	1.11 (1.04–1.17)	<0.01	1.13 (1.05–1.22)	<0.01	1.06 (0.97–1.15)	0.20
TC (continuous)	0.91 (0.80–1.03)	0.12			1.22 (1.05–1.42)	0.01	1.25 (1.06–1.47)	0.01
TG (continuous)	0.95 (0.81–1.11)	0.49			0.97 (0.80–1.17)	0.73
PNI (continuous)	0.97 (0.95–1.00)	0.06			1.00 (0.97–1.03)	0.98
PLR (continuous)	1.00 (1.00–1.00)	0.07			1.00 (1.00–1.00)	0.11
SII (continuous)	1.00 (1.00–1.00)	0.54		0.35	1.00 (1.00–1.00)	0.56

The bold P value less than 0.05 was considered statistically significant. HR, hazard ratio; CI, confidence interval; TNM, tumor node; SII, systemic immune-inflammation index; PNI, prognostic nutritional index; PLR, platelet-lymphocyte ratio; TC, total cholesterol; TG, triglycerides.