TABLE 2.
Glycated albumin, HbA1c and CGM metrics across gestation.
| 12 weeks | 20 weeks | 24 weeks | 28 weeks | 32 weeks | 36 weeks | |
|---|---|---|---|---|---|---|
| CGM metrics | ||||||
| Mean glucose, mg/dl | 119 (112, 128) | 119 (110, 126) | 119 (112, 128) | 121 (114, 130) | 121 (112, 130) | 117 (108, 128) |
| Mean glucose, mmol/L | 6.6 (6.2, 7.1) | 6.6 (6.1, 7.0) | 6.6 (6.2, 7.1) | 6.7 (6.3, 7.2) | 6.7 (6.2, 7.2) | 6.5 (6.0, 7.0) |
| TIR, % | 59 (54, 65) | 63 (57, 68) | 61 (55, 66) | 61 (55, 66) | 64 (58, 69) | 68 (62, 74) |
| TAR, % | 29 (23, 35) | 27 (21, 33) | 29 (23, 35) | 31 (24, 37) | 29 (22, 35) | 25 (18, 32) |
| TBR, % | 12 (8, 15) | 10 (7, 13) | 10 (7, 14) | 9 (5, 12) | 8 (4, 11) | 7.2 (4, 11) |
| TBR2, % | 7 (4, 10) | 5 (3, 7) | 6 (3, 9) | 5 (3, 7) | 4 (1, 7) | 4 (2, 6) |
| Coefficient of variation, % | 40 (37, 43) | 38 (35, 40) | 37 (34, 39) | 36 (33, 38) | 35 (32, 38) | 34 (32, 37) |
| Glucose SD, mmol/L | 2.7 (2.4, 2.9) | 2.5 (2.2, 2.7) | 2.5 (2.2, 2.7) | 2.4 (2.2, 2.6) | 2.3 (2.1, 2.6) |
2.2 (2.0, 2.5) |
| Laboratory glycaemic markers | ||||||
| CGM‐group (n = 20) | ||||||
| Glycated albumin, % | 12.1 (11.3, 13.0) | 12.4 (11.5, 13.3) | 11.3 (10.4, 12.2) | 11.0 (10.1, 11.9) | 10.2 (9.3, 11.1) | 9.3 (8.4, 10.3) |
| HbA1c, % | 6.1 (5.8, 6.4) | 5.8 (5.6, 6.1) | 5.7 (5.4, 6.0) | 6.2 (5.6, 6.3) | 6.1 (5.8, 6.4) | 6.1 (5.8, 6.5) |
| HbA1c, mmol/mol | 44 (40, 47) | 40 (37, 44) | 39 (36, 42) | 44 (38, 45) | 43 (40, 47) | 44 (40, 47) |
| Non‐CGM group (n = 20) | ||||||
| Glycated albumin, % | 11.6 (10.2, 12.9) | 11.1 (9.7, 12.5) | 10.3 (8.9, 11.8) | 10.0 (8.6, 11.5) | 10.0 (8.5, 11.5) | 9.2 (7.6, 10.8) |
| HbA1c, % | 6.4 (6.0, 6.9) | 6.0 (5.5, 6.4) | 5.8 (5.4, 6.3) | 5.9 (5.4, 6.4) | 6.1 (5.5, 6.7) | 6.1 (5.6, 6.7) |
| HbA1c, mmol/mol | 47 (42, 52) | 42 (37, 47) | 40 (35, 45) | 41 (35, 46) | 43 (37, 49) | 44 (37, 50) |
Note: Data presented as mean with 95% confidence intervals, adjusted predictions. CGM metrics were calculated from 103 14‐days periods across gestation with >70% coverage.
Abbreviations: CGM, continuous glucose monitoring; HbA1c, glycated haemoglobin A1c; SD, standard deviation; TAR, time above range >140 mg/dl (>7.8 mmol/L); TBR, time below range <63 mg/dl (<3.5 mmol/L); TBR2, time below range <54 mg/dl (<3.0 mmol/L); TIR, time in range 63–140 mg/dl (3.5–7.8 mmol/L).