Table 3.

Estimated Hazard Ratio and 95% Confidence Intervals using Fine-Gray proportional hazard regression models for the association between combined ALT abnormality strata and severe liver disease.^†

	Fine and Gray Regression Models
	Unadjusted Model		Adjusted Model†
Combined ALT Strata	HR	95% CI	HR	95% CI
Low ALT (ref.)
High ALT	1.79	1.50 – 2.13	2.01	1.69 – 2.40
Persistently High ALT	2.19	1.85 – 2.59	2.89	2.43 – 3.44
Pairwise ALT Strata Comparison
Persistently High vs. High	1.22	1.04 – 1.44	1.44	1.22 – 1.69

^†The adjusted model controls for gender, race, marital status, smoking history, body mass index, and the presence of hypertension, diabetes, hyperlipidemia, cardiovascular disease, hypothyroidism, and kidney disease.