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. 2022 Oct 31;13:1027841. doi: 10.3389/fendo.2022.1027841

Table 2.

Sensitivity analysis on “high quality” studies (NOS≥8).

Item N of studies N of patients/controls MD (95% CI) I2 P-value
PA vs. EH
Serum calcium 4 466/532 -0.03 (-0.09, 0.03)* 84% <0.01
Urine calcium 3 456/350 0.76 (0.41, 1.12) 0% 0.50
Serum PTH 4 466/532 2.59(1.69, 3.50) 82% <0.01
Serum 25-OHD 4 466/532 -1.51 (-6.43, 3.41) 60% 0.06
Before-treatment vs. After-treatment PA
Serum calcium 7 323/323 -0.08 (-0.11, -0.05) 70% <0.01
Urine calcium 6 284/284 2.17 (1.70, 2.65) 0% 0.66
Serum PTH 8 354/354 3.19 (2.03, 4.36) 90% <0.01
Serum 25-OHD 7 305/305 -7.00 (-14.13, 0.13)* 76% <0.01
Unilateral vs. Bilateral PA
Serum calcium 5 338/285 -0.03 (-0.04, -0.01)* 35% 0.19
Urine calcium 3 245/211 0.20 (-0.24, 0.64) 40% 0.19
Serum PTH 5 338/285 1.54 (1.04, 2.04) 0% 0.51
Serum 25-OHD 5 338/285 -4.94 (-7.87, -2.00) 0% 0.93

N, number; MD, mean difference; 95% CI, 95% Confidence Intervals; * MD results changed after excluding “low quality” studies.