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The parameter used in the HCM model variant. Pi_ref denotes the reference value for inorganic phosphate (Pi) in the simulations. Ap2 is a variable influencing detachment of crossbridges. F1 and F2 are coefficients affecting pre-rotational states in XB cycling as also used in (Margara et al., 2021).
| # | Parameter | Control value | Value in HCM model variant |
|---|---|---|---|
| 1 | Pi_ref (mM) | 2 | 18.9 |
| 2 | MgADP (mM) | 36 × 10–3 | 72 × 10–3 |
| 3 | ap2 coef | 1 | 0.315 |
| 4 | F1 | 1 | 1.3 |
| 5 | F2 | 1 | 1.3 |
