TABLE 3.
Modifications to the model parameters to simulate the effect of Mavacamten. A, B, C, D, and E are coefficients in Eqs 15–19 affecting PXB-XBPreR regulation, Pi-dependent transition in PXB-XBPreR, XBpreR-XBpostR regulation, Proton-dependent transition in XBpostR-XBpreR, and MgATP-dependent transition from XBpostR-PXB, respectively. BL is the baseline value given in Table 1. Default values of A-E, ap1 and ap3 coefs., F1 and F2 are equal to 1.
| # | Parameter | Values in 0.5 µM MAVA |
|---|---|---|
| 1 | Kon (mM−1 s−1) | BL × 1.048 |
| 2 | nperm | BL × 0.688 |
| 3 | A | 0.26 |
| 4 | B | 0.4 |
| 5 | C | 5.4 |
| 6 | D | 0.4 |
| 7 | E | 2.39 |
| 8 | ap1 coef | 1.45 |
| 9 | ap3 coef | 0.28 |
| 10 | F1 | 0.1 |
| 11 | F2 | 0.1 |