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. 2022 Oct 31;12:1015587. doi: 10.3389/fonc.2022.1015587

Figure 2.

Figure 2

Overview of ncRNAs involved in the regulation of the pyroptosis pathways in cancer. LINC00958 was found to initiate AIM2 inflammasome-dependent pyroptosis. By contrast, circNEIL3 prevented DNA damage-induced AIM2 inflammasome activaiton, thereby restraining the pyroptosis process. HOTTIP was capable of suppressing NLRP1 inflammasome-mediated pyroptosis. miR-21-5p and GAS5 could activate the canonical inflammasome pathway by regulating ASC. miR-214, miR-181, miR-200b, ADAMTS9-AS2 and MEG3 were reported to facilitate the assembly of NLRP3 inflammasome, whereas miR-556-5p, miR-195, SNHG7, XIST and GSEC exerted the opposite action. miR-125b limited the activity of caspase-1, hence blocking the canonical inflammasome pathway. miR-145 and miR-497 drove the pyroptosis pathway by promoting GSDMD expression or activation. However, RP1-85F18.6 inhibited GSDMD cleavage and thus repressed pyroptoic cell death. CircPUM1 negatively regulated caspase-3 to interrupt the related pyroptosis pathway. NEAT1 and miR-155-5p had opposite effects on GSDME-executed pyroptosis. DAMPs, damage-associated molecular patterns; PAMPs, pathogen-associated molecular patterns; AIM2, absent in melanoma 2; ASC, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain; NLRP1, nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 1; NLRP3, nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3; GSDMD, gasdermin D; GSDMD-N, the N-terminal domain of gasdermin D; IL-1β, interleukin-1β; IL-18, interleukin-18; LPS, lipopolysaccharide; GSDME, gasdermin E; GSDME-N, the N-terminal domain of gasdermin E.