Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 31;13:1020624. doi: 10.3389/fimmu.2022.1020624

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Al-Qahtani, Pantazi, Alhamlan, Alothaid, Matou-Nasri, Sourvinos, Vergadi and Tsatsanis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Inhibition of AKT abrogated the immunosuppressive action of SARS-CoV-2 S protein. A549 cells were treated with the pan-AKT inhibitor MK2206 (5μM) for 24 hours and then stimulated with SARS-CoV-2 S (50ng/ml) for 12 hours. Secretion of IL8 (A), IL6 (B) and TNFα (C) decreased in the presence of SARS-CoV-2 S, an effect which was less evident in MK2206-treated cells. Data are illustrated in bars and plotted as median with range (n=4 biological replicates per group). Statistical analysis was performed with Kruskal - Wallis test. *p < 0.05.