Table 1.

Studies targeting HMGB1 in PD.

S.N.	Study model	Treatment	Mode of inhibition	Observations	References
1	MPTP-induced PD mouse model	Anti-HMGB1 mAb	Neutralization	Inhibits dopaminergic cell death and reduces RAGE and TNF-α levels	(20)
2	6-OHDA-induced PD mouse model	Anti-HMGB1 mAb	Neutralization	inhibits the activation of microglia, the destruction of the BBB and the expression of IL-1β and IL-6 Reduced PD behavioral symptoms	(28)
3	MPTP-induced PD mouse model	EP	Release inhibition	Restoration of dopaminergic neuron numbers in substantia nigra and striatum	(29)
4	MPTP-induced PD zebrafish larvae model	GL	Release inhibition	Increases the length of DA neurons in the zebrafish brain and reduces the number of apoptotic cells in the zebrafish brain	(30)