Table 10.

Studies targeting HMGB1 in MS.

S.N.	Study model	Treatment	Mode of inhibition	Observations	References
1	MOG-induced EAE mouse model	anti-HMGB1 mAb	Neutralization	Improves clinical and pathological severity of EAE	(127)
2	MOG-induced EAE mouse model	GL	Release inhibition	Decreases HMGB1 release	(128)