Table 11.

Studies targeting HMGB1/TLR4 pathway in MS.

S.N.	Study model	Treatment	Mechanism	Observations	References
1	MOG-induced EAE mouse model	MAT	Inhibition of HMGB1/TLR4/NF-κB pathway	Relief of inflammatory demyelination and activation of astrocytes and microglia/macrophages in the central nervous system of EAE rats	(131)