Table 12.

Studies targeting HMGB1 in ALS.

S.N.	Study model	Treatment	Mode of inhibition	Observations	References
1	Transgenic SOD1G93A mice	Anti-HMGB1 mAb	Neutralization	Briefly improves hindlimb grip strength in mice early in the disease, but not prolonged survival Reduces spinal cord TNF-α and complement C5a receptor 1 gene expression, but did not affect overall glial activation	(134)