Table 7.

Studies targeting HMGB1 in depression.

S.N.	Study model	Treatment	Mode of inhibition	Observations	References
1	CUMS-induced depression mouse model	GL	Release inhibition	Improves chronic stress-induced depression	(106)
2	CUMS-induced depression mouse model	EP	Release inhibition	Depressed behavioral tendency	(108)
3	LPS-induced depression mouse model	GL	Release inhibition	Eliminates LPS-induced cognitive dysfunction, anxiety and depression-like behaviors	(113)
4	PSNL-induced depression mouse model	Anti-HMGB1 mAb	Neutralization	Reduces microglia activation and anxiety-depression-like behavior	(114)